This is a vitamin D 3 cheat sheet I have developed. I believe it has lots of information you will find useful? On my website I do write about mental health. On google scholar countless articles about vitamin D3, magnesium and mental health. Showing how important it is. This cheat sheet is a work in progress: I am writing out essentially part or all of what follows for almost every question concerning vitamin D3 and magnesium. So I put together the following cheat sheet. I am not giving medical advice just my personal opinions. Ideally you work with a medical professional who really understands vitamin D3. Ok there are five levels of vitamin D3 effects as I see it. 1. First Inadequate vitamin D3 which is typically blood plasma(BPL) that are less than approximately 50 ng/ml and daily doses of 10,000 IU a day of vitamin D3 a day. BPLs that are less than 50 ng/ml and daily doses of 50 ng/ml. * 2: low physiological BPLs -which are vitamin D3 BPLs of 50-100 ng/ml requiring a daily dose of 10-25,000 IU a day. 1,2 3. Optimal BPLs-requiring a BPL of 100-140 ng/ml requiring 30,000 IU a day of vitamin D3. 1,2 4. maximal vitamin D3 dosing-which is based on a a parathyroid hormone level in the very low normal range. Parathyroid hormone(PtH) BPLs are the best though indirect indication of maximum vitamin D3 function. The BPL that Dr. Coimbra uses to treat autoimmune diseases.1,2 5. Potentially toxic BPLs-perhaps almost impossible to develop. Requiring vitamin D3 BPLs of approaching 400 ng/ml. Even then this occurs at those BPLs in less than one percent of people. Frankly extremely rare one might go this high or above 200 ng/ml.except in those who are extremely ill. If so you should be under the care of a medical doctor well versed in vitamin D3. If pregnant and or going to be best to speak with a Dr. Coimbra trained doctor or one who follows the LGS Protocol by Dr. Eduardo Patrick MD if going to take higher doses. As one concern is adequate vitamin A but prenatal vitamins The first three levels are based on vitamin D3 BPLs and the last one on (PTH) BPLs. Often optimal BPLs also have a PtH BPL in the very low normal range consistent with the PtH levels found in maximal vitamin D3 dosing. Of note as long as vitamin D3 BPLs are less than 200 ng/ml you do not need to check 24 hour urine calcium levels. The maximal dosing may and typically is required in those with vitamin D receptor gene mutation(s). As they more likely to develop autoimmune diseases, diseases like Chron’s disease and multiple sclerosis. These individuals may require daily doses of up to 1,000 IU/kg/day of vitamin D3. This would be in what is considered a “standard adult male” who weighs 172 lbs or 78.2 kg a daily vitamin D3 dose of up to 78,000 IU a day. In medical school they taught us that this is the medical definition of the average weight of an average adult male. In those with BPLs of vitamin D3 above 200 ng/ml it is wise to check a 24 hour urine calcium after being at this BPL after 6-8 weeks and say every three months A colleague mixes his daily dose in a liter of water. Sipping it over the course of the day. That way resulting in a more gentle ingestion of magnesium over the course of the day. Most people are magnesium deficient or borderline deficiente. So typically people start out magnesium deficient. That is body stores of magnesium. The typical magnesium “blood” one that is checked in your typical blood work is not accurate. As the serum, the fluid from which this is done and surrounding your cells,,only has less than one percent of one’s total body’s magnesium. The majority is in one’s cells and bones. I once had a patient who was so anxious he was going to ER two to three times a week. I tried every prescription medication to treat it. Nothing helped. I then out of desperation put him on magnesium as I described above. He never had another anxiety attack. As endorphins and enkephalins are to pain what magnesium is to anxiety! It is the body’s anxiolytic! The reason when vitamin D3 deficient as a adult requires so much magnesium. As besides being most people have low magnesium levels or magnesium deficient is taking supplemental vitamin D3 requires lots of magnesium for absorption, conversion to different forms and its enzymatic reactions. Also when taking at least low physiological doses to reach at least low physiological BPLs or greater BPLs or maximal vitamin D3 dosing requires magnesium. If one suffers osteoporosis they may also require lots of calcium, but probably also phosphorus and protein to rebuild one’s bones.
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