So, in most case by increasing the active form of vitamin D3 results in augmented calcium absorption from the small intestine. This is adequate in most cases as we have lots of calcium in our food. So typically, don’t need more. Yes, you can excrete it in your urine.


However, if your arteries are already damaged this excess calcium may quickly find a home before you can excrete it. Remember calciferol- the active form of vitamin D3 is under tight control. So, if calcium levels rise calciferol level will decrease. 

And as I will explain below there are other hormones involved in controlling the calcium levels in our blood. Yes, calcifediol-the blood form of vitamin D3 at extremely high blood levels can affect calcium levels and is not controlled by parathyroid levels. 

The problem is there are no studies to show at what blood level, calcifediol starts to influence calcium. Otherwise the higher the blood level of calcium the lower the calciferol level which results in lower calciferol levels with more calcium excreted, and active absorption of calcium stops. 

See as the blood calcium level tries to increase parathyroid levels drop. Which reduces the production of calciferol in the kidneys. Also, another hormone I will explain in a bit kick in. Though at some point the blood form-calcifediol blood level becomes high enough that calcium blood levels rise. 

This is typically extremely high at levels above 300 ng/ml to possibly 400 ng/ml. The possibility is that calcifediol at lower blood levels than those could result in more calcium being absorbed. Calcifediol is about 1,000 times less effective than calciferol on the vitamin D receptors (VDR).  

The VDR that for one initiate augmented calcium absorption. However, to my knowledge the effects of calcifediol on calcium balance or at what level it starts to cause significant calcium augmented absorption has not been studied. 

So, no one really knows if and at what blood level below typically 300-400 ng/ml that it starts to significantly affect the VDR. Though until these levels are reach the bodies compensation mechanisms prevent blood calcium levels from rising. 

The point is there “may be” at some point due to rising blood levels of calcifediol, more calcium is “flowing” through the body. We just don’t know at what blood level this starts or how significant it is until we reach the extremely high levels above 300 ng/ml or higher. 

When some develop hypercalcemia. Even at those levels its effects on calcium could have nothing to do with its absorption. That is calcium’s absorption from the gut but could solely be caused by its decreased excretion through the kidneys or increased bone breakdown. We do not know.

To reiterate, no inflammation/HTN, no damage so no plaque so then calcium deposition to cause atherosclerosis. Atherosclerosis probably or never is a problem in a person who is healthy. Yes, perhaps some genetic anomaly that is rare but in general no. 


But in a chronically inflamed, hypertensive and ill person extra calcium may be an issue. May be or may be not. We don’t know if more calcium “flowing” through the body exacerbates atherosclerosis. Or if higher doses of calcifediol, short of blood levels in the 300-400 ng/ml can in some increase calcium. 

That is because we don’t know if all people with these blood levels develop hypercalcemia. As for one all the scientific studies I am aware of use such low doses and usually don’t measure its blood level. This is important as blood levels are the most important and accurate way to measure of the effect of it. 

What I do know and important is without the beneficial effects of higher, I argue optimal doses and blood levels, of vitamin D3 one is sure to develop atherosclerosis and all the other “winter Syndrome” diseases I have written about before. 1

The reason I am even discussing possibilities is that is what real scientist do. They have a hypothesis and then really look at what happens. So, I am willing to challenge my beliefs that optimal doses and blood levels benefits far out way risk if there are any. 

Yes, my biases but I am not pulling punches in exploring what is reality. For me the only way to find out was testing on myself. See as at this time I started developing the peripheral vascular disease (PVD)-blue toes I had been on these much higher doses of vitamin D3 for over three years. 

Over three years before these issues showed up. At the time I was under a great deal of stress. It was only after I stopped taking an antacid medication and took large doses of calcium that my symptoms of PVD showed up. 

*The information posted above is for educational purposes only. Always check with your doctor before initiating any changes in your medical treatment. If you do not, then The Two-Minute Health Fact, Dr. Judson Somerville, nor The Optimal Dose is responsible!


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