Vitamin D3 and Diabetes Type I and II. 6/7

Those suffering from type II diabetes though will have to also use will power to reduce calories. It will be difficult. As they are fighting their brain that is with type II diabetes their brain is “blind” to leptin and insulin. Thus, their brain is telling them they are starving or at the least they need more fuel (food).

The situation is, like I wrote about type II diabetes, more complex. The symptoms of winter syndrome which I have discussed before but to refresh are poor sleep, impaired immune system and impaired metabolism.  With all these systems not functioning properly they put a huge strain on the body.

Making it more likely to have inflammation and not repair the cause or damage it causes. In this way optimal doses of vitamin D3 further works to reverse and/or prevent type II diabetes. As I was taught in medical school, we age roughly 2-3 days physically for everyday we suffer from diabetes. Now back to type I diabetes.

For example, in children who contract type one diabetes a recent study demonstrated a connection with low vitamin D3 levels. 1 In this article they believe it may be due to vitamin D3 effect on the immune system. They recommend tracking vitamin D3 levels in children to assure they are not susceptible.

They also recommend those who develop it to supplement with vitamin D3. Another article suggests it, low vitamin D3 blood levels are associated with progression of type 1 diabetes. 2 That there are stages to developing full blown type I diabetes.

Then a recent study in the journal Cell shows that the vitamin D receptor (VDR) when triggered by vitamin D and a substance called I-BRD9 results in the increased production of genes. 3 Genes, that protect cells among them beta cells. Beta cells are the ones that produce insulin.

I-BDR9 also brought elevated blood sugar levels in mice back to normal. I-BRD9 is what is called a selective cell active chemical-probe. I understand and read a lot of science but not really clear what this is. But if correct it appears to be a tool they use in pharmaceutical research.

Basically, I believe it is a tool they use to stimulate receptors, in this case VDR. If it has an effect, which in this case it did. Then they then use that information to try to develop a molecule (drug) to replicate this and to be used clinically. That is if this molecule by itself cannot accomplish that!

As this chemical was directly applied to the cells it did not have to survive digestion and pass through the liver like an oral medication. Nor has it been tested in humans. This makes sense and prior to today never heard of it but then again, I am clinical not bench research oriented.

So, vitamin D3 interacting with the VDR can if properly stimulated a cascade that significantly increases the production of protective and anti-inflammatory proteins in the blood. Perhaps there are and this appears to be the case, such stimulators already in our system.

Perhaps it is vitamin K2? Or as I am thinking about this and this makes more sense, it isn’t that vitamin D3 alone is inadequate. It is that most people do not have adequate amounts of vitamin D3. Enough to stimulate enough cells through the vitamin D receptor to produce enough anti inflammatory proteins.

Thus, if say billions of cells were able to do this, as I wrote about in earlier blog posts almost every cell has VDR. Then they could and would produce adequate amounts and not need to be stimulated. That makes the most sense. Do we really want to substitute a pharmaceutical for the real thing?

Think about fat blocking weight loss pills and the nightmare they caused. When in fact they were essentially trying to crudely mimic what vitamin D3 does naturally. I certainly could be wrong but from what I have seen optimal doses do I doubt it.

1. Munchen HZ, (February 27,2014). Type 1 diabetes: Vitamin D deficiency occurs in early stage. <www.sciencedaily.com/releases/2014/02/140227115426.htm>.
2. Raab J, Giannopoulou EZ, Ziegler AG, et al. (May 2014). Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with diabetes progression. Diabtologia. 57(5):902-908.
3. Theodoulou NH, Bamborough P, Bannister AJ, et al. (2016). Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. J Med Chem. 25;59(4):1425-39.

*The information posted above is for educational purposes only. Always check with your doctor before initiating any changes in your medical treatment. If you do not, then The Two-Minute Health Fact, Dr. Judson Somerville, nor The Optimal Dose is responsible!