In my book I noted that it was my opinion the optimal blood level of vitamin D3 is 100-140 ng/ml. Yes, I referenced a dose that is multiple times what they in the VITAL study consider a high dose and over time that dose resulted in most people in that range.
But some needed a larger then what I consider a typical optimal dose and rarely did one or to out of the thousands tested needed less. I am not yet listing the optimal dose in my blog yet as I will soon but want to finish explaining my approach to optimal health with vitamin D3.
The initial blood levels I found of vitamin D3 in the thousands of patients I measured ranged from 4-53 ng/ml. I only had one patient whose initial level was in the 50’s ng/ml, 3 in the 40’s ng/ml and most in the 20’-35 ng/ml. I had around a dozen below 10 ng/ml and perhaps 20% in the 10-20 ng/ml range.
No not exact but I believe it is important to have a general idea of what blood levels of the patients I treated. No, you cannot extrapolate this to any other group as I have no idea what “normal” blood range for any other group is.
However, I would guess and from the data I have seen this is not that different from what the normal distribution of people’s blood levels in the US. I measured their blood level as any scientist will tell you, if available, that is the most accurate way to determine the effects of a medicine.
That don’t typically when they discuss toxicity of a substance list the dose but the blood level as people react differently. Thus the VITAL study by not focusing on blood levels but dose resulted in poor scientific study set up. No, it is a horribly thought out scientific study.
Did they forget how to set up a study? Or did they want it to look like it was a robust study to purposely fool people? Yes, using blood levels would have taken more money but it would actually result in useful information. Albeit information we already knew.
That is extremely low blood levels compared to optimal blood levels don’t have much effect. All I know is if I set up or had anything to do with this VITA study, I would be embarrassed. I could understand using dose if it was a substance that people didn’t already naturally have the substance in the body.
If the blood levels didn’t vary widely, and it didn’t take much higher dose then they recommended to significantly increase the blood levels. But it does occur naturally in the body as we can produce it. The blood levels in people does vary widely.
It does take much higher doses to achieve what they consider to be high blood levels and unless the upper blood level limit often given for “safe” use, 100 ng/ml, were so deadly toxic that you must stay far from it, there is no reason for the investigators in this study to not use much higher dosing.
But it is not toxic at 100ng/ml but as I found the opposite. It appears by keeping this vague it is easier to scare people. Then as inaccurate as this study setup is let’s look deeper to dosing. If 2,000 IUs a day for five years increased the blood level roughly by about 10.0 ng/ml.
And initially they list that 32.2 percent of the study participants blood levels were in the 20-30 ng/ml blood range. Based on this, then a significant percentage were below this level throughout the study. As despite being given “high” doses of vitamin D3 they would on average never have reached a “normal” blood level.
A level that has been determined by US government as minimal normal blood level, 30 ng/ml. Thus, a large percentage of participants would still be at deficient levels even after taking this dose “high” dose throughout the study.
So perhaps a few in this group reached a normal level but that certainly isn’t a high blood level, nor does it account for any whose blood level was below 10 ng/ml. How many in participants in this VITAL study were below 20 ng/ml blood level at the start of the study we do not know. Again, showing the poor study setup.
*The information posted above is for educational purposes only. Always check with your doctor before initiating any changes in your medical treatment. If you do not, then The Two-Minute Health Fact, Dr. Judson Somerville, nor The Optimal Dose is responsible!